Premature ejaculation is a condition in which ejaculation occurs sooner than desired, often within about one minute of penetration, and causes personal distress or relationship difficulties.

Sertraline increases serotonin activity, which helps delay the ejaculation reflex. This side effect can be used therapeutically to improve ejaculatory control.

No. Sertraline is not specifically approved for premature ejaculation, but it is commonly prescribed off-label for this purpose based on clinical evidence.

Clinical studies show that sertraline can significantly increase intravaginal ejaculatory latency time, often multiplying baseline duration by two to eight times.

Doses typically range from 25 to 100 mg daily. Treatment usually starts at a lower dose and is adjusted based on response and side effects.

Improvement may be noticed within several days to one week, which is generally faster than its effect on mood disorders.

Sertraline works best when taken daily. On-demand use may provide some benefit, but daily dosing generally produces more consistent results.

Many men experience a noticeable increase in ejaculatory control. For example, ejaculation that previously occurred within 30 seconds may extend to several minutes.

Yes. Sertraline (Zoloft) is only available with a prescription. A licensed healthcare provider needs to evaluate your symptoms and decide if it’s the right treatment before you can start it.

Yes. You can receive a prescription for Sertraline (Zoloft) after completing a virtual consultation with a licensed Mount Sinai Urology CME provider. Learn more about our network of expert urologists.

No. Sertraline (Zoloft) is not sold over the counter. You’ll need a valid prescription from a licensed healthcare provider.

Yes. Mount Sinai Urology CME providers can issue new prescriptions or refills for Sertraline (Zoloft) following an online consultation, if it’s appropriate for your care. Your medication will be shipped directly to your home in plain, discreet packaging.

No. Sertraline manages symptoms while it is being taken. The delaying effect typically diminishes after the medication is discontinued.

Risks include sexual side effects such as reduced libido, emotional blunting, gastrointestinal upset, and withdrawal symptoms if stopped abruptly.

In some men, sertraline may contribute to erectile difficulties, although delayed ejaculation is more common than erectile dysfunction.

Yes, when prescribed appropriately by a healthcare provider. A medical evaluation is necessary to ensure it is safe and suitable.

Yes. Alternatives include other SSRIs such as paroxetine, topical anesthetic creams, behavioral techniques, and dapoxetine.

Yes. It may be combined with behavioral therapy or topical treatments under medical supervision to improve outcomes.

Individuals taking monoamine oxidase inhibitors, certain interacting medications, or those with known hypersensitivity to sertraline should avoid it. Caution is advised in people with bipolar disorder or bleeding disorders.

Sertraline can be effective in adult men of various ages, though older individuals may be more sensitive to side effects and may require lower starting doses.

Regular follow-up appointments are recommended to assess effectiveness, side effects, mood changes, and overall sexual function.

Yes. Premature ejaculation often has psychological components such as performance anxiety. Counseling or sex therapy can improve long-term outcomes.

Some studies suggest sertraline may affect sperm parameters, but the clinical significance remains unclear. Men concerned about fertility should consult their healthcare provider.